艰难梭菌毒素A
梭菌
艰难梭菌毒素B
大肠杆菌
产气荚膜梭菌
医学
作者
Emma Meader,Melinda J. Mayer,Dietmar Steverding,Simon R. Carding,Arjan Narbad
出处
期刊:Anaerobe
[Elsevier]
日期:2013-08-01
卷期号:22: 25-30
被引量:53
标识
DOI:10.1016/j.anaerobe.2013.05.001
摘要
Clostridium difficile is a leading cause of hospital-acquired diarrhoea and represents a major challenge for healthcare providers. Due to the decreasing efficacy and associated problems of antibiotic therapy there is a need for synergistic and alternative treatments. In this study we investigated the use of a specific bacteriophage, ΦCD27, in a human colon model of C. difficile infection. Our findings demonstrate a significant reduction in the burden of C. difficile cells and toxin production with phage treatment relative to an untreated control, with no detrimental effect on commensal bacterial populations. The results demonstrate the potential of phage therapy, and highlight the limitations of using phages that have lysogenic capacity.
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