Selective decontamination of the digestive tract reduced intensive care unit and hospital mortality in adults

de Jonge E, Schultz MJ, Spanjaard L, et al . Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 2003;362:1011–6.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q Does selective decontamination of the digestive tract (SDD) reduce mortality and acquisition of resistant bacteria in adult patients in the intensive care unit (ICU)? ### ![Graphic][5] Design: randomised controlled trial. ### ![Graphic][6] Allocation: {concealed}*. ### ![Graphic][7] Blinding: unblinded. ### ![Graphic][8] Follow up period: to hospital discharge. ### ![Graphic][9] Setting: an ICU at an academic medical centre in Amsterdam, The Netherlands. ### ![Graphic][10] Patients: 1090 patients >18 years of age (mean age 60 y, 59% men; based on n = 934), who had an expected duration of mechanical ventilation ⩾48 hours, an expected ICU stay of ⩾72 hours, or both. Exclusion criteria: previous ICU admission within 3 months, known hypersensitivity to study medication, pregnancy, perceived imminent death, and participation in another study. ### ![Graphic][11] Intervention: 537 … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253Dde%2BJonge%26rft.auinit1%253DE.%26rft.volume%253D362%26rft.issue%253D9389%26rft.spage%253D1011%26rft.epage%253D1016%26rft.atitle%253DEffects%2Bof%2Bselective%2Bdecontamination%2Bof%2Bdigestive%2Btract%2Bon%2Bmortality%2Band%2Bacquisition%2Bof%2Bresistant%2Bbacteria%2Bin%2Bintensive%2Bcare%253A%2Ba%2Brandomised%2Bcontrolled%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252803%252914409-1%26rft_id%253Dinfo%253Apmid%252F14522530%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(03)14409-1&link_type=DOI [3]: /lookup/external-ref?access_num=14522530&link_type=MED&atom=%2Febnurs%2F7%2F2%2F47.atom [4]: /lookup/external-ref?access_num=000185564600007&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif [11]: /embed/inline-graphic-7.gif