右美托咪定
异氟醚
异丙酚
发情周期
七氟醚
麻醉
血压
医学
丸(消化)
动脉血
内科学
内分泌学
镇静
作者
Kathleen Vincent,Olivia G. Mallari,Emmaline J. Dillon,Victoria G. Stewart,Angel J. Cho,Yuanlin Dong,Andrea G. Edlow,Fumito Ichinose,Zhongcong Xie,Ken Solt
标识
DOI:10.1016/j.bja.2023.03.025
摘要
Background Although sex differences in anaesthetic sensitivity have been reported, what underlies these differences is unknown. In rodents, one source of variability in females is the oestrous cycle. Here we test the hypothesis that the oestrous cycle impacts emergence from general anaesthesia. Methods Time to emergence was measured after isoflurane (2 vol% for 1 h), sevoflurane (3 vol% for 20 min), dexmedetomidine (50 μg kg−1 i.v., infused over 10 min), or propofol (10 mg kg−1 i.v. bolus) during proestrus, oestrus, early dioestrus, and late dioestrus in female Sprague–Dawley rats (n=24). EEG recordings were taken during each test for power spectral analysis. Serum was analysed for 17β-oestradiol and progesterone concentrations. The effect of oestrous cycle stage on return of righting latency was assessed using a mixed model. The association between righting latency and serum hormone concentration was tested by linear regression. Mean arterial blood pressure and arterial blood gases were assessed in a subset of rats after dexmedetomidine and compared in a mixed model. Results Oestrous cycle did not affect righting latency after isoflurane, sevoflurane, or propofol. When in the early dioestrus stage, rats emerged more rapidly from dexmedetomidine than in the proestrus (P=0.0042) or late dioestrus (P=0.0230) stage and showed reduced overall power in frontal EEG spectra 30 min after dexmedetomidine (P=0.0049). 17β-Oestradiol and progesterone serum concentrations did not correlate with righting latency. Oestrous cycle did not affect mean arterial blood pressure or blood gases during dexmedetomidine. Conclusions In female rats, the oestrous cycle significantly impacts emergence from dexmedetomidine-induced unconsciousness. However, 17β-oestradiol and progesterone serum concentrations do not correlate with the observed changes.
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