医学
热疗
背景(考古学)
放射治疗
膀胱癌
顺铂
丝裂霉素C
化疗
癌症
临床试验
肿瘤科
外科
内科学
古生物学
生物
作者
Oliver J. Ott,Udo S. Gaipl,Allison Lamrani,Rainer Fietkau
标识
DOI:10.1016/j.semradonc.2022.10.011
摘要
For decades, the antineoplastic potential of hyperthermia alone or in combination with radiotherapy and/or chemotherapy has been subject of intensive preclinical and clinical research in various tumor entities. The clinical evidence on the beneficial effects of additional hyperthermia in combination with intravesical Mitomycin C for superficial non-muscle-invasive bladder cancer as well as for deep regional microwave hyperthermia techniques applied during an external beam radiotherapy or chemoradiation treatment for more advanced tumors are summarized. In some series, deep regional hyperthermia in combination with an initial transurethral resection and Cisplatin-based chemoradiation increased the 5-year overall survival rates up to 20%. The presented data justifies a fresh irrespective chance for mild regional hyperthermia in the context of new progressive prospective trials on multimodality treatment for bladder preservation.
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