肽聚糖
微生物学
金黄色葡萄球菌
大肠杆菌
革兰氏阳性菌
细菌
革兰氏阴性菌
抗菌活性
化学
生物
抗生素
生物化学
基因
遗传学
作者
Jiang Feng,Chengteng Cai,Lei Gao,Su X,Shoufa Han
出处
期刊:ACS omega
[American Chemical Society]
日期:2022-12-30
卷期号:8 (2): 2485-2490
标识
DOI:10.1021/acsomega.2c06964
摘要
Microbicides with distinct antibacterial mechanisms show potential to combat multi-drug resistance bacteria. We herein report peptidoglycan-directed chemical ligation (PGCL) between alkyne-bearing vancomycin and an azide-tagged cationic polymer. The former binds peptidoglycan and inhibits peptidoglycan crosslinking, while the latter interferes the integrity of the bacterial membrane. PGCL results in enhanced bactericidal activity against Gram-positive Staphylococcus aureus (S. aureus) over Gram-negative Escherichia coli (E. coli). These data indicate the potential of PGCL to selectively and synergistically inhibit Gram-positive pathogens via dual modality antibacterial mechanisms of peptidoglycan-inhibiting antibiotics and bacterial membrane-disrupting polycations.
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