医学
化疗
肿瘤浸润淋巴细胞
肿瘤科
卡莫司汀
细胞疗法
癌症
内科学
环磷酰胺
免疫疗法
干细胞
遗传学
生物
摘要
Melanomas have long been considered to be immunogenic tumors. Although anti–programmed death 1 (PD-1) therapy has been approved worldwide as first-line treatment, many patients do not benefit from it, so there is an important therapeutic gap. Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) was described in the 1980s by Rosenberg and colleagues.1 This personalized treatment for cancer is based on the infusion of autologous T lymphocytes that have been obtained directly from surgically removed autologous tumors and then expanded in culture with the use of interleukin-2 stimulation. Both preconditioning lymphodepletion with high-dose, nonmyeloablative chemotherapy and the intravenous administration of high-dose . . .
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