Copper‐Induced Supramolecular Assemblies for Biomedical Applications

Copper is an essential transition metal in living systems, primarily functioning as a cofactor in enzymes, and is tightly regulated by trafficking proteins. Excessive intracellular copper ions can induce cuproptosis—a distinct form of cell death closely associated with mitochondrial energy metabolism disruption. The unique chemical and biological properties of copper have also inspired the development of copper‐induced supramolecular self‐assemblies, which hold great promise in artificial catalysts, drug delivery, and catalytic therapeutics. This concept explores the fundamental design principles underlying copper‐induced self‐assembly in small molecules, peptides, and polymers, along with their emerging biomedical applications. Finally, key challenges and future directions in this rapidly evolving field are highlighted.