An electrochemical sensor based on copper oxide nanoparticles loaded on a mesoporous MCM-41 for non-enzymatic detection of glucose

Numerous researchers are interested in glucose monitoring systems for diabetes mellitus, which is a serious health problem on a global scale. Due to its low detection limit, quick reaction, and good stability, the new generation of electrochemical glucose biosensors has attracted a lot of research attention. However, enzymatic electrochemical sensors are highly susceptible to changes in temperature, humidity, and pH, which can adversely affect their performance. Herein, we developed a non-enzymatic electrochemical sensor for the detection of glucose by using copper oxide (CuO) nanoparticles loaded on mesoporous substrate mobile crystalline material-41 (MCM-41) by the standard solvothermal method and confirmed by standard characterization techniques. The CuO@MCM-41-based electrochemical sensor having redox properties was designed to quantitatively determine glucose, and the relative mechanism was explored. The designed sensor showed a broad linear response in the range of 83 μM - 1.5 mM for glucose with a rapid response time of 4 s, a sensitivity of 17.23 mAcm−2mM−1, and a LOD of 16 nM. The CuO@MCM-41 composite possesses good characteristics that point to the possible commercial applications of mesoporous material-based composites for nonenzymatic electrochemical glucose sensing.