寨卡病毒
病毒学
小头畸形
黄病毒
接种
免疫
医学
生物
病毒
免疫学
抗体
儿科
作者
Hao-Long Dong,Zhili Chen,Mei-Juan He,Jiazhen Cui,Hui‐Ming Cheng,Qingyang Wang,Xianghua Xiong,Gang Liu,Huipeng Chen
出处
期刊:Vaccines
[MDPI AG]
日期:2024-02-19
卷期号:12 (2): 215-215
标识
DOI:10.3390/vaccines12020215
摘要
Zika virus (ZIKV) is an emerging flavivirus that causes congenital syndromes including microcephaly and fetal demise in pregnant women. No commercial vaccines against ZIKV are currently available. We previously generated a chimeric ZIKV (ChinZIKV) based on the Chaoyang virus (CYV) by replacing the prME protein of CYV with that of a contemporary ZIKV strain GZ01. Herein, we evaluated this vaccine candidate in a mouse model and showed that ChinZIKV was totally safe in both adult and suckling immunodeficient mice. No viral RNA was detected in the serum of mice inoculated with ChinZIKV. All of the mice inoculated with ChinZIKV survived, while mice inoculated with ZIKV succumbed to infection in 8 days. A single dose of ChinZIKV partially protected mice against lethal ZIKV challenge. In contrast, all the control PBS-immunized mice succumbed to infection after ZIKV challenge. Our results warrant further development of ChinZIKV as a vaccine candidate in clinical trials.
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