癌症干细胞
生物
癌变
核糖核酸
癌症
计算生物学
癌症研究
基因表达
癌细胞
肿瘤微环境
基因
遗传学
作者
Jonas Cerneckis,Qi Cui,Wei Liu,Yanhong Shi
出处
期刊:Cancer treatment and research
日期:2023-01-01
卷期号:: 25-47
标识
DOI:10.1007/978-3-031-45654-1_2
摘要
Post-transcriptional regulation of gene expression shapes the cell state both in health and disease. RNA modifications-especially N6-methyladenosine (m6A)-have recently emerged as key players in RNA processing that depends on a sophisticated interplay between proteins of the RNA modification machinery. Importantly, the RNA epitranscriptome becomes dysregulated in cancer and promotes cancer-associated gene expression programs as well as cancer cell adaptation to the tumor microenvironment. At the top of the tumor hierarchy, cancer stem cells (CSCs) are master regulators of tumorigenesis and resistance to therapeutic intervention. Therefore, defining how RNA modifications influence the CSC state is of great importance for cancer drug development. In this chapter, we summarize the current knowledge of the roles of RNA modifications in shaping the CSC state and driving gene expression programs that confer stem-like properties to CSCs, promote CSC adaptation to the local microenvironment, and endow CSCs with metastatic potential and drug resistance.
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