生物膜
噬菌体疗法
鲍曼不动杆菌
噬菌体
微生物学
抗生素
抗生素耐药性
菌血症
生物
细菌
铜绿假单胞菌
大肠杆菌
遗传学
生物化学
基因
作者
Ilona Grygiel,Olaf Bajrak,Michał Wójcicki,Klaudia Krusiec,Ewa Jończyk‐Matysiak,Andrzej Górski,Joanna Majewska,Sławomir Letkiewicz
出处
期刊:Antibiotics
[Multidisciplinary Digital Publishing Institute]
日期:2024-11-08
卷期号:13 (11): 1064-1064
被引量:5
标识
DOI:10.3390/antibiotics13111064
摘要
Acinetobacter baumannii—a multidrug-resistant (MDR) pathogen that causes, for example, skin and soft tissue wounds; urinary tract infections; pneumonia; bacteremia; and endocarditis, particularly due to its ability to form robust biofilms—poses a significant challenge in clinical settings. This structure protects the bacteria from immune responses and antibiotic treatments, making infections difficult to eradicate. Given the rise in antibiotic resistance, alternative therapeutic approaches are urgently needed. Bacteriophage-based strategies have emerged as a promising solution for combating A. baumannii biofilms. Phages, which are viruses that specifically infect bacteria, offer a targeted and effective means of disrupting biofilm and lysing bacterial cells. This review explores the current advancements in bacteriophage therapy, focusing on its potential for treating A. baumannii biofilm-related infections. We described the mechanisms by which phages interact with biofilms, the challenges in phage therapy implementation, and the strategies being developed to enhance its efficacy (phage cocktails, engineered phages, combination therapies with antibiotics). Understanding the role of bacteriophages in both biofilm disruption and in inhibition of its forming could pave the way for innovative treatments in combating MDR A. baumannii infections as well as the prevention of their development.
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