人类白细胞抗原
造血干细胞移植
移植
造血细胞
免疫学
造血
干细胞
生物
医学
细胞生物学
抗原
内科学
作者
Daniela Cardozo,Jeane Eliete Laguila Visentainer,Cármino Antônio De Souza
出处
期刊:IntechOpen eBooks
[IntechOpen]
日期:2024-11-21
标识
DOI:10.5772/intechopen.1007711
摘要
NK cells are cytotoxic lymphocytes, representing about 5–15% of circulating mononuclear lymphocytes, and are defined as CD3-CD56 + NKp46+. They play crucial roles in host defense by recognizing and eliminating virus-infected and tumor cells without prior sensitization. The function of NK cells is regulated by a repertoire of receptors that issue activating or inhibitory intracellular signals. The ligands for these receptors can be diverse. Recent studies show that interactions between NK cell receptors and their ligands can depend on the peptide presented by HLA at the time. This chapter explores key findings in the literature regarding the interaction between NK cell receptors, HLA, and peptides and aims to understand the immunological mechanisms involved in these interactions and how these interactions might impact hematopoietic stem cell transplantation.
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