Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications

The CRISPR/Cas9 systems contain three modes: I. plasmid DNA encoding both Cas9 and sgRNA; II. Cas9 mRNA and sgRNA; III. Cas9 protein and sgRNA. We summarized the application of the synthesized nanomaterials for delivery the CRISPR/Cas9 systems.