Axial‐to‐Point Chirality Transfer: Chromium(VI)‐Catalyzed Hydroxylative Dearomatization of 2‐Naphthols

Axial‐to‐point chirality transfer is an important strategy for the construction of chiral centers, where the axial chiral reagents are mostly limited to atropomerically stable ones. In this work, a Cr(VI)‐catalyzed enantioselective hydroxylative dearomatization (via axial‐to‐point chirality transfer) of axially chiral 2‐naphthols is presented. This transformation proceeds efficiently across a broad range of axially chiral 2‐naphthols, yielding hydroxylative dearomatized products in good yields (up to 85%) with excellent enantioselectivities (up to > 99% ee) and enantiospecificity (up to > 99% es).