Synergistic Effects of Chitosan Nanoparticles and Seaweed Extract in Accelerating Burn Wound Healing and Combating Microbial Infections

Abstract Burns and chronic wounds represent significant medical problems, particularly when amplified by infections that delay healing and result in complications. The development of safer and more effective natural medications with antimicrobial and wound healing properties is necessary. Therefore, this study investigates the antimicrobial and burn healing properties of seaweed extract/chitosan nanoparticles as a natural agent. Chitosan was prepared successfully with a degree of deacetylation of 84.8%. A combination of Seaweed and chitosan nanoparticles (CNPs‐SW) was investigated for antibacterial, antifungal and burn healing activities. CNPs‐SW showed antibacterial action against Staphylococcus aureus and Pseudomonas aeruginosa . Also, it showed antifungal activity against Candida albicans . Additionally, the CNPs‐SW combination as a topical hydrogel accelerated the burn healing by 18.07%. On the 16 th day post‐burning, the healing percentages reached 80.50 ± 0.86% for the control group and 98.26 ± 1.05% for the treatment group. These results indicated that the combination of chitosan and seaweed together as a topical gel is an effective agent for treating burns with antimicrobial properties.