A Comprehensive Review of Advances in Molecular Diagnostics and Treatment of Trypanosomiasis

This review aims to give a thorough account of the latest development in the molecular diagnostics and therapy of Trypanosomiasis due to Trypanosoma brucei and Trypanosoma cruzi. We focus on recent diagnostic approaches such as PCR, LAMP, and CRISPR applying high specificity to increase diagnostic accuracy and diagnosis at early stages. In regard to limitations of the present study, the review also articulates issues like drug resistance and demand for safer therapeutic products. In addition, we aim to identify new biomarkers in diseases and for following up disease or treatment biomarkers. This review means to outline certain priorities for research and stress the role of international cooperation in order to optimally understand and manage Trypanosomiasis as a medical and social issue.