Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

Background: The hair cycle is key to understanding the onset of alopecia. We investigated the effects of culturing human hair follicle-derived keratinocytes (HFK) and human follicle dermal papilla cells (HFDPC) under specific conditions to determine the effects of products secreted by the former on hair-related gene expression in the latter to clarify intercellular signal transduction between the tissues that make up the hair root.