磷脂酰丝氨酸
班级(哲学)
MHC II级
化学
主要组织相容性复合体
生物化学
计算机科学
人工智能
基因
磷脂
膜
作者
Arisa Hori,Saori Toyoura,Megumu Fujiwara,Rin-ichiro Taniguchi,Yasutaka Kano,Tomoyoshi Yamano,Rikinari Hanayama,Masafumi Nakayama
出处
期刊:iScience
[Elsevier]
日期:2024-05-01
卷期号:27 (5): 109704-109704
标识
DOI:10.1016/j.isci.2024.109704
摘要
In addition to cross-presentation, cross-dressing plays an important role in the induction of CD8+ T cell immunity. In the process of cross-dressing, conventional dendritic cells (DCs) acquire major histocompatibility complex class I (MHCI) from other cells and subsequently prime CD8+ T cells via the pre-formed antigen-MHCI complexes without antigen processing. However, the mechanisms underlying the cross-dressing pathway, as well as the relative contributions of cross-presentation and cross-dressing to CD8+ T cell priming are not fully understood. Here, we demonstrate that DCs rapidly acquire MHCI-containing membrane fragments from dead cells via the phosphatidylserine recognition-dependent mechanism for cross-dressing. The MHCI dressing is enhanced by a TLR3 ligand polyinosinic-polycytidylic acid (polyI:C). Further, polyI:C promotes not only cross-presentation but also cross-dressing in vivo. Taken together, these results suggest that cross-dressing as well as cross-presentation is involved in inflammatory diseases associated with cell death and type I IFN production.
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