医学
结节病
肾素-血管紧张素系统
肉芽肿性炎症
炎症
醛固酮
血管紧张素II
内科学
免疫学
病理
受体
血压
作者
Elliott D. Crouser,M Julián,Landon W. Locke,Sabahattin Bicer,Jonah R. Mitchell,Arindam Singha,Patrick J. Kramer,Murugesan V. S. Rajaram,Subha V. Raman
标识
DOI：10.1164/rccm.202402-0265oc
摘要
Sarcoidosis is a granulomatous disorder of unclear cause notable for abnormal elevation of blood and tissue ACE1 (angiotensin converting enzyme 1) levels and activity. ACE1 regulates the renin-angiotensin-aldosterone system (RAAS), the terminal product of which is aldosterone, which selectively engages mineralocorticoid receptors to promote inflammation.
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