神经传导速度
舒张期
心脏病学
热传导
拉伤
诱导多能干细胞
机制(生物学)
心肌病
心脏周期
材料科学
内科学
医学
生物医学工程
心力衰竭
化学
物理
复合材料
血压
生物化学
胚胎干细胞
量子力学
基因
作者
Ronald Ng,Gökhan İlhan,Paul Stankey,Fadi G. Akar,Stuart G. Campbell
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2023-12-01
卷期号:325 (6): H1373-H1385
标识
DOI:10.1152/ajpheart.00709.2022
摘要
We uncover a novel mechanotransductive mechanism that unmasks conduction defects in arrhythmogenic cardiomyopathy (ACM). Using a novel dynamic bioreactor and human-induced pluripotent stem cell (hiPSC)-derived engineered heart tissue (EHT), we apply strain at distinct intervals during the cardiac cycle. Imposing mechanical strain during diastole selectively slows conduction velocity. To our knowledge, this is the first time that the effect of mechanical loading during a specific part of the cardiac cycle has been shown to cause conduction deficits in ACM.
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