化学
对映选择合成
分子内力
胺化
废止
哌啶
非对映体
催化作用
烯丙基重排
钯
序列(生物学)
立体化学
组合化学
有机化学
药物化学
生物化学
作者
Jian Zhang,Hao Yuan,Tianying Zhang,Zhichao Chen,Wei Du,Ying‐Chun Chen
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-07
卷期号:25 (45): 8133-8138
标识
DOI:10.1021/acs.orglett.3c03261
摘要
An enantioselective (4 + 2) reaction between 1,3-dienes and N-cyano imines has been developed under Pd(0) catalysis, proceeding through a cascade vinylogous addition and intramolecular allylic amination sequence. 2,6-cis-Disubstituted-1,2,3,6-tetrahydropyridines were furnished as single diastereomers in moderate to good yields and enantiocontrol. Moreover, a more challenging three-component (2 + 2 + 2) annulation of 1,3-dienes, N-cyano imines, and activated alkenes was efficiently realized to afford piperidines with high structural complexity, albeit with moderate enantioselectivity.
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