病态的
转录因子
机制(生物学)
缺氧(环境)
发病机制
肺动脉高压
缺氧诱导因子1
缺氧诱导因子
医学
癌症研究
药理学
生物信息学
病理
内科学
基因
生物
化学
遗传学
氧气
认识论
有机化学
哲学
作者
Jing Wan,Jongheop Yi,Fengdan Wang,Chao Zhang,Aiguo Dai
摘要
Hypoxia inducible factor-1(HIF-1), a heterodimeric transcription factor, is composed of two subunits (HIF-1α and HIF-1β). It is considered as an important transcription factor for regulating oxygen changes in hypoxic environment, which can regulate the expression of various hypoxia-related target genes and play a role in acute and chronic hypoxia pulmonary vascular reactions. In this paper, the function and mechanism of HIF-1a expression and regulation in hypoxic pulmonary hypertension (HPH) were reviewed, and current candidate schemes for treating pulmonary hypertension by using HIF-1a as the target were introduced, so as to provide reference for studying the pathogenesis of HPH and screening effective treatment methods.
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