Preparation Technique of Paeonol HP-β-CD Inclusion Complex with Orthogonal Design

Objective:To screen and optimize the preparation conditions of paeonol HP-β-CD inclusion complex(paeonol HP-β-CD) with stirring method.Methods:The load-drug and recovery of paeonol were adopted as the index,host-guest weight ratio,concentration of HP-β-CD and stirring time as factors,have been investigated in the techniques of paeonol-HP-β-CD.Results: The load-drug and recovery of paeonol-HP-β-CD were respective(8.88±0.06)% and(96.63±0.97)% by optimizing conditions which were host-guest weight ratio 1∶7,10% HP-β-CD and stirring time 1 h. At the same time,its solubility of paeonol was increased.Conclusion: The optimizing techniques fit to prepare paeonol HP-β-CD in industry.