Agriculture as non-point pollution source is the main factor which led to water pollution. At the beginning of non-point source pollution study, there are basically two study methods ,one is applying models related to hydrologic model to simulate and estimate non-point source pollution load ,another is common soil loss equation. A practical estimation method of non-point source pollution load-mean concentration method was established. Combining non-point source pollution load with 3S technology ,jointing with water quality model and applying them into water quality management became the new growth of non-point source pollution study .Recently, non-point source pollution study began to search the joint of non-point source pollution load and river water quality model.