Analysis of Arsenic Metabolites in Patients with Acute Promyelocytic Leukemia Treated with Arsenic Trioxide

Arsenic trioxide is widely used in treating human acute promyelocytic leukemia( APL) and have made great achievements. The efficacy and toxicity of arsenic depend on the concentrations of various arsenic metabolites in the body. So it is very important to detect various arsenic metabolites in APL treated with arsenic trioxide. In recent years,people start to know more about arsenic metabolites,and the methods of detectionhave been improved. Some scholars have studied specifics of arsenic metabolites in blood and urine of patients treated with arsenic trioxide at different stages,even in cerebro-spinal fluid and saliva,depicting the concentrations of various arsenic metabolites in the body and changes during the APL treatment.