Objective:To discuss the clinical characteristics of painless myocardial infarction. Method: 121 patients with acute myocardial infarction (AMI) were divided into 81 cases of CPMI group and 40 cases of NPMI group. The results were compared. Result: Painless myocardial infarction often accompanied by pulmonary heart disease and type 2 diabetes mellitus. It is popular in old people with many complications and high mortality rate (20.5%). Conclusion: Painless myocardial infarction have poor prognosis. It can be improved by timely diagnosis and effective treatment.