Amphotericin B for Treatment of Invasive Fungal Infections in 40 Patients with Malignant Hematologic Diseases

Objective To observe the therapeutic effect and side effects of amphotericin B for invasive fungal infections in patients with malignant hematologic diseases.Methods 40 patients with malignant hematologic dis-eases were given amphotericin B,5~50mg/d per day for 8~66days(average time 22 days).Results The clinical efficacy rate of amphotericin B was 75%,and fungal elimination rate was 63.6%.Among the side effects,rigor and fever were present in 57.5% of the patients.Hypokalaemia was found in 40%,nausea and vomiting were found in 20% and nephrotoxicity in 15%.Conclusion Amphotericin B is still a high-efficiency drug in treatment of invasive fungal infections though its many side effects.Our study indicates that if it is used properly and hepatic and renal function are monitored,amphotericin B is a relatively safe and effective drug.