Objective: To investigate the splenic artery embolization for hypersplenism of cirrhosis and the clinical efficacy and safety. Methods: A retrospective analyzed of our hospital from February 2006 December to 2010 cirrhosis and hypersplenism treated 56 patients clinical data, all patients were treated with splenic embolization observed and compared before surgery, hypersplenism and to improve the situation the occurrence of complications. Results: 56 cases of patients with hypersplenism after partial splenic embolization total efficiency of 94.4% (53/56), 3 cases ineffective. 56 patients after 1 year follow-up, 2 cases of recurrence, the recurrence rate of 3.57%. 56 patients, 1 week after surgery, 44 patients platelets were10.0×109/L. There was a certain percentage of postoperative complications. Conclusion: Cirrhosis and portal hypertension, hypersplenism treatment for patients with PSE, have different blood cell values increased, reaching the treatment of hypersplenism purposes, reduced gastrointestinal bleeding, improved quality of life.