Antitumor Activity of Cord Blood Mononuclear Cells

Objective To explore the killing efficacy of cord blood mononuclear cells in HO9810 and the activation effect of rhIFNα-2b on it.Methods Mononuclear cells were isolated from fetal blood and adult peripheral blood respectively,whose killing efficacy in HO9810 at the presence or absence of rhIFNα-2b were measured with MTT.Results The natural killing efficacy of cord blood mononuclear cells was lower than that of the peripheral blood.When activated,however,it was enhanced markedly and could be equal to that of the latter.Conclusions The mononuclear cells in the cord blood can be activated into killing cells by rhIFNα-2b,which shows increased killing efficacy to HO9810 and have a promised future in antitumor immunotherapy.