Saccharomyces cerevisiae is an important industrial micro-organism,which is the soul of the wine quality. In anaerobic conditions,Saccharomyces cerevisiae has played a crucial role in the process from grape to wine. The relationship of wine yeast and wine brewing was described. And the manipulation methods occurred in wine industrialization fermentation process,the current application of modern scientific and technological means to breed wine yeast species were also introduced. Finally,the current situation and future prospects for the wine brewing industry was discussed and viewed.