Objective: To study the cause of appearing the damp pathogen in Northwest Dryness Syndrome, and to expound the relation of its pathogenesis. Methods: To synthesize analyzing the relation of damp and dryness pathogen in Northwest Dryness Syndrome guiding by the TCM theory and basing on the clue of epidemiological survey. Results: The pathogenesis relation of damp and dryness pathogen in Northwest Dryness Syndrome changing each other had four types: first, dryness pathogen stagnated nutritive and defensive Qi, furthermore, the outside was dryness and the inside was damp; second, dryness happening suddenly caused the Qi weaken,body fluid stagnated causing damp; third, dryness reached extreme will be damp, the damp changed from dryness; forth, damp blocked functional activities of Qi causing dryness came from the inside. Conclusion: Damp from the Northwest Dryness Syndrome is the inner damp, caused by the outside dryness attacking human body initiate struggle between Vital-Qi and pathogenic Factors.