Effect of Low-dosage Hemodialysis on Cytokine and Alexin

Objective To investigate the effect of low-dosage hemodialysis on cytokine and residual renal function.Methods 30 ure- mic patients whose residual renal function could preserve(Ccr5ml/min urine 800 ml/d).Were divided into two groups and then were giv- en hemodialysis treatment.20 patients(experimental group)performed in the low-dosages hemodialysis and hemodialysed 1～1.5 times weekly and the other 10 patients(Routine Hemodialysis)performed routine hemodialysis,2 times weekly.Results Compared with the rou- tine hemodialysis group,the experiment group produced less IL-1,IL-6,TNF-α.But more.IL-10.While residual renal function declined slowly after nine months.There was no significant difference in hemodialysis effect between the two groups.Conclusion Low-dosage hemodialysis 1～1.5 times a week was feasible for uremic patients if their residual renal function preserred(Ccr5ml/min,Urine800ml/d)and dehy- dration was less 2 kg on each hemodialysis.The low-dosage hemodialysis treatment is the optimal therapy for early uremia without dehydra- tion,if the hemodialysis efficacy can be assured.