化学
Stille反应
全合成
分子内力
三氟甲磺酸
丙烯酸酯
位阻效应
二烯
立体化学
生物碱
有机化学
组合化学
催化作用
单体
天然橡胶
聚合物
作者
Artem Shvartsbart,Amos B. Smith
摘要
Presented here is a full account on the development of a strategy culminating in the first total synthesis of the architecturally complex daphniphyllum alkaloid, (-)-calyciphylline N. Highlights of the approach include a highly diastereoselective, intramolecular Diels-Alder reaction of a silicon-tethered acrylate; an efficient Stille carbonylation of a sterically encumbered vinyl triflate; a one-pot Nazarov cyclization/proto-desilylation sequence; and the chemoselective hydrogenation of a fully substituted diene ester.
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