Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats

Objective:To explore the effect of Anwei decoction on the expression of intestinal trefoil factor mRNAs(TFF3 mRNAs) in chronic atrophic gastritis(CAG) rats.Method: Thirty six rats were randomly divided into three groups: model group,Anwei decoction group and Weifuchun group.CAG was induced by N-methy-N-nit ro-N-nitroguanidine(MNNG).The expression of TFF3 mRNA in rats' gastric mucosas was determined by real-time polymerase chain reaction(real-time PCR).Result: The ratio of TFF3 mRNA/β-actin was 0.95 ± 0.23,0.43 ± 0.04,0.64 ± 0.04 respectively in the model group,Anwei decoction group and Weifuchun group.Compared with that in the model group,the expression of TFF3 mRNA was remarkably reduced in Anwei decoction group and Weifuchun group(P 0.01).Anwei decoction showed better effect than Weifuchun(P 0.05).Conclusion: Anwei decoction may treat CAG by reducing the expression of TFF3 mRNA in gastric mucosas.