表观遗传学
疾病
DNA甲基化
药物开发
组蛋白
生物
基因沉默
生物信息学
药物发现
药品
计算生物学
医学
遗传学
基因
药理学
基因表达
内科学
出处
期刊:Current Drug Discovery Technologies
[Bentham Science]
日期:2019-12-11
卷期号:16 (4): 386-391
被引量:2
标识
DOI:10.2174/1570163815666180419154954
摘要
Epigenetic mechanisms comprising of DNA methylation, histone modifications and gene silencing by RNA interference have been strongly linked to the development and progression of various diseases. These findings have triggered research on epigenetic functions and signal pathways as targets for novel drug discovery. Dietary intake has also presented significant influence on human health and disease development and nutritional modifications have proven important in prevention, but also the treatment of disease. Moreover, a strong link between nutrition and epigenetic changes has been established. Therefore, in attempts to develop novel safer and more efficacious drugs, both nutritional requirements and epigenetic mechanisms need to be addressed.
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