STAPHYLOKINASE: A BOON IN MEDICAL SCIENCES – REVIEW

Every year most of the deaths were leaded by cardio and cerebrovascular disorders around the globe. The use of first or second generation thrombolytics may rise several side effects like bleeding in biological system at the time of treatment. New generation thrombolytics plays an important role in the treatment of thromboembolic disorders which leads to the death. An ideal fibrin specific plasminogen activator, staphylokinase converts a precursor, plasminogen to active enzyme, plasmin to dissolve the blood clot during thrombolytic therapy and it also capable to destroy the normal components of hemostatic system which leads to life threatening consequence and also death. Out of four different thrombolytics which are available in market like alteplase, reteplase, streptokinase and tenecteplase, streptokinase was widely used drug because of its low cost. But, to overcome the hurdles like bleeding and reocculsion efforts have been made to construct the more potent staphylokinase devoid of risk. In this review, progressive development on staphylokinase has been discussed. Key words: Cerebrovascular disorders, thrombolytics, fibrin specific, streptokinase, staphylokinase, reocclusion.