医学
安慰剂
泌尿系统
入射(几何)
泌尿科
放射治疗
优势比
下尿路症状
随机对照试验
置信区间
内科学
癌症
前列腺
病理
物理
替代医学
光学
作者
C. Cowan,C. B. Hutchison,Thom Cole,Sarah Barry,James Paul,Nicholas Reed,John M. Russell
标识
DOI:10.1016/j.clon.2011.05.009
摘要
Aims Radical pelvic radiotherapy is one of the main treatment modalities for cancers of the bladder and cervix. The side-effects of pelvic radiotherapy include urinary symptoms, such as urinary frequency and cystitis. The therapeutic effects of cranberry juice in the prevention and treatment of urinary tract infections in general are well documented. The purpose of this study was to evaluate the effectiveness of cranberry juice on the incidence of urinary tract infections and urinary symptoms in patients undergoing pelvic radiotherapy for cancer of the bladder or cervix. Materials and methods The study was a placebo-controlled, double-blind design. Participants were randomised to receive cranberry juice, twice a day (morning and night) for the duration of their radiotherapy treatment and for 2 weeks after treatment (6 weeks in total) or a placebo beverage, for the same duration. Results The incidence of increased urinary symptoms or urinary tract infections was 82.5% on cranberry and 89.3% on placebo (P=0.240, adjusted odds ratio [cranberry/placebo] 0.48, 95% confidence interval 0.14–1.63). Conclusions The power of the study to detect differences was limited by the below target sample size and poor compliance. Further research is recommended, taking cognisance of the factors contributing to the limitations of this study.
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