Paroxysmal Nocturnal Hemoglobinuria Following Drug-induced Aplastic Anemia

Article1 December 1964Paroxysmal Nocturnal Hemoglobinuria Following Drug-induced Aplastic AnemiaJ. M. QUAGLIANA, M.D., G. E. CARTWRIGHT, M.D., M. M. WINTROBE, M.D., PH.D., F.A.C.P.J. M. QUAGLIANA, M.D.Search for more papers by this author, G. E. CARTWRIGHT, M.D.Search for more papers by this author, M. M. WINTROBE, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1045 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptParoxysmal Nocturnal Hemoglobinuria (PNH) (1,2) is a rare disorder of unknown etiology characterized by an intracorpuscular defect that renders erythrocytes more susceptible to hemolysis in an acid medium. The disease is characterized by a chronic hemolytic anemia that is usually accompanied by leukopenia, thrombocytopenia, erythroid hyperplasia of the bone marrow, hemoglobinemia, hemoglobinuria, and hemosiderinuria. The course is often complicated by recurrent infections and venous thromboses. Because of the varied and often bizarre clinical picture, the correct diagnosis may not be made despite long periods of observation and study (3).Bone marrow failure has been observed to occur during the course...References1. WINTROBE MM: Clinical Hematology. 5th ed., Lea and Febiger, Philadelphia, 1961. Google Scholar2. CROSBY WH: Paroxysmal nocturnal hemoglobinuria. Relation of clinical manifestations to underlying pathogenic mechanisms. Blood 8: 769, 1953. CrossrefMedlineGoogle Scholar3. GAITHER JC: Paroxysmal nocturnal hemoglobinuria. A successful imposter. New Eng. J. Med. 265: 421, 1961. CrossrefMedlineGoogle Scholar4. CROSBY WH: Paroxysmal nocturnal hemoglobinuria. 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DACIELEWIS JVSM: Paroxysmal nocturnal hemoglobinuria: variation in clinical severity and association with bone marrow hypoplasia. Brit. J. Haemat. 7: 442, 1961. CrossrefMedlineGoogle Scholar11. LETMAN H: Possible paroxysmal nocturnal hemoglobinuria with pronounced pancytopenia, reticulocytopenia, and without hemoglobinuria simulating aplastic anemia. Blood 8: 842, 1952. CrossrefGoogle Scholar12. ULLMANHORNABRAHAMVAN SLYCK ASRCJDEJ: Paroxysmal nocturnal hemoglobinuria. Report of two cases with atypical features, autopsy findings, and review of pathophysiology. Henry Ford Hosp. Med. Bull. 11: 135, 1963. MedlineGoogle Scholar13. ANDRÉDREYFUSVERGOZNAJMAN RBDA: Remarques sur un cas de maladie de Marchiafava-Micheli, évoluant longtemps sous l'aspect d'une pancytopénie chronique. Presse Méd. 71: 610, 1963. MedlineGoogle Scholar14. MARTIN H: Atypische paroxysmale nächtliche Hämoglobinurie (Anämia Marchiafava-Micheli) kompliziert durch eine idiopathische erworbene hämolytische Anämie und vorübergehende Markaplasie. Folia Haemat. 73: 268, 1955. Google Scholar15. CARTWRIGHT GE: Diagnostic Laboratory Hematology. 3rd ed., Grune & Stratton, New York, 1963. Google Scholar16. LEWIS SM: Red-cell abnormalities and hemolysis in aplastic anemia. Brit. J. Haemat. 8: 322, 1962. CrossrefMedlineGoogle Scholar17. DAMESHEK W: Paroxysmal nocturnal hemoglobinuria (Marchiafava-Micheli syndrome). Bull. New Eng. Med. Center 4: 224, 1942. Google Scholar18. DACIEGILPIN JVA: Refractory anaemia (Fanconi type). Its incidence in three members of one family, with in one case a relationship to chronic haemolytic anaemia with nocturnal hemoglobinuria (Marchiafava-Micheli disease or 'nocturnal haemoglobinuria'). Arch. Dis. Child. 19: 155, 1944. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Salt Lake City, UtahFrom the Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah.This study was supported by a research grant AM-04489 and a graduate training grant TL AM-5098 from the National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to M. M. Wintrobe, M.D., 175 East 21st South St., Salt Lake City, Utah. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLong-Term Survival After Marrow Transplantation for Paroxysmal Nocturnal Hemoglobinuria with Aplastic AnemiaJEFFREY SZER, MB., B.S., H. JOACHIM DEEG, M.D., ROBERT P. WITHERSPOON, M.D., ALEXANDER FEFER, M.D., C. DEAN BUCKNER, M.D., E. 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Treatment of Acquired Aplastic AnaemiaDifficulties in the Evaluation of Lead PoisoningThe Aplastic Anaemia–Paroxysmal Nocturnal Haemoglobinuria Syndrome 1 December 1964Volume 61, Issue 6Page: 1045-1052KeywordsAplastic anemiaHemoglobinHemolytic anemiaMetabolic disordersObservational studiesPathogenesisPatientsResearch grantsSaltsThrombosis Issue Published: 1 December 1964 PDF DownloadLoading ...