激发试验
声鼻测量
医学
可视模拟标度
抗原
鼻激发试验
皮内注射
皮肤病科
鼻子
免疫学
麻醉
外科
病理
替代医学
作者
John H. Krouse,Kamran Sadrazodi,Kristy Kerswill
标识
DOI:10.1016/j.otohns.2004.03.024
摘要
OBJECTIVE Examine the efficacy of epicutaneous and intradermal testing in predicting response to nasal provocation with timothy antigen. STUDY DESIGN AND SETTING Prospective study. Subjects were tested with Multi‐Test II (MT). Subjects with negative wheals were tested with a 1:500 intradermal injection of timothy. They had baseline assessment of nasal cross‐sectional area (CSA) using acoustic rhinometry and underwent nasal provocation with increasing timothy concentrations. CSA was assessed and nasal visual analog scale (VAS) completed with each concentration. RESULTS Sensitivity and specificity of MT in predicting nasal response to provocation were 87% and 86%. Intradermal testing increased sensitivity to 93%. Hierarchical linear modeling (HLM) demonstrated that subjects positive to skin testing had significant reductions in CSA and worsening VAS scores with increasing concentrations of nasally delivered antigen. CONCLUSION AND SIGNIFICANCE Epicutaneous testing with the Multi‐Test II offers 87% sensitivity and 86% specificity in assessing timothy grass reactivity.
科研通智能强力驱动
Strongly Powered by AbleSci AI