上睑下垂
炎症体
目标2
NLRC4型
分泌物
发病机制
半胱氨酸蛋白酶1
生物
细胞生物学
疾病
免疫学
免疫系统
炎症
医学
微生物学
生物化学
病理
作者
Till Strowig,Jorge Henao‐Mejia,Eran Elinav,Richard A. Flavell
出处
期刊:Nature
[Springer Nature]
日期:2012-01-01
卷期号:481 (7381): 278-286
被引量:1929
摘要
Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines and a form of cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and mucosal immune responses. We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases.
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