谷胱甘肽
磁共振成像
多发性硬化
氧化应激
扩大残疾状况量表
医学
内科学
体内
抗氧化剂
病变
核磁共振
核医学
病理
内分泌学
化学
放射科
生物化学
免疫学
生物
酶
生物技术
物理
作者
In‐Young Choi,Phil Lee,Douglas R. Denney,Sharon Lynch
标识
DOI:10.1177/1352458510384010
摘要
Disability levels for patients with secondary progressive multiple sclerosis (SPMS) often worsen despite a stable MRI T(2) lesion burden. The presence of oxidative stress in the absence of measurable inflammation could help explain this phenomenon. In this study, the assessment of an in vivo marker of oxidative stress, cerebral glutathione (GSH), using magnetic resonance chemical shift imaging (CSI) is described, and GSH levels were compared in patients with SPMS and healthy controls.To assess whether GSH, a key antioxidant in the brain, is lower in the SPMS patients compared to matched controls.Seventeen patients with SPMS (Expanded Disability Status Scale=4.0-7.0; length of MS diagnosis=19.4 ± 7 years) and 17 age- and gender-matched healthy controls were studied. GSH levels were measured in the fronto-parietal regions of the brain using a specially designed magnetic resonance spectroscopy technique, CSI of GSH, at 3T.The levels of GSH were lower for SPMS patients than for controls, the largest reduction (18.5%) being in the frontal region (p=0.001).The lower GSH levels in these patients indicate the presence of oxidative stress in SPMS. This process could be at least partially responsible for ongoing functional decline in SPMS.
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