Abstract The white‐rot fungus Phanrochaete chrysosporium has the ability to degrade a wide variety of structurally diverse organic compounds, including a number of environmentally persistent organopollutants. The unique biodegradative abilities of this fungus appears to be dependent upon its lignin‐degrading system. The non‐specific and partially extracellular nature of this system suggests that it may be useful as a supplementary means to treat organochemical wastes.