黄芩素
羟脯氨酸
肝纤维化
四氯化碳
药理学
层粘连蛋白
医学
基质金属蛋白酶
黄芩
透明质酸
纤维化
肝星状细胞
内科学
四氯化碳
内分泌学
化学
病理
细胞外基质
生物化学
中医药
有机化学
替代医学
解剖
作者
Hai Sun,Qing–Ming Che,Xin Zhao,Xiaoping Pu
标识
DOI:10.1016/j.ejphar.2010.01.002
摘要
Baicalein was a major bioactive flavonoid derived from Radix Scutellariae in Xiao-Chai-Hu-Tang which was commonly used to treat chronic hepatitis and liver fibrosis in China. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl4) in rats and investigate its possible protective mechanism. The antifibrotic effects of baicalein were assessed directly by hepatic histology and indirectly by measuring levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), hepatic hyaluronic acid, laminin and procollagen type III (PCIII) in serum, as well as hydroxyproline and matrix metalloproteinases (MMPs) in liver. In addition, we further investigated protein synthesis of platelet derived growth factor (PDGF) β receptor which has been identified as attractive target for therapeutic intervention. CCl4 treatment increased levels of AST, ALT, hyaluronic acid, laminin, and PCIII in serum, as well as hydroxyproline and MMPs in liver. Baicalein treatment (20, 40, or 80 mg/kg for 10 weeks) dose-dependently decreased levels of these markers. Baicalein also reduced inflammation, destruction of liver architecture, and collagen accumulation and significantly inhibited protein synthesis of PDGF-β receptor. Together, our results suggest that chronic baicalein administration inhibits stellate cell activation and proliferation by the down-regulation of PDGF-β receptor and prevents the development of CCl4 induced liver fibrosis in rats.
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