现象
速尿
药品
化学
生化工程
药理学
医学
内科学
物理
工程类
量子力学
作者
Micaela Giannetti,Viviana Claudia Canale,Laura Micheli,Maurizio Fiori,Claudia Mazzuca,Antonio Palleschi
出处
期刊:Molecules
[MDPI AG]
日期:2023-01-02
卷期号:28 (1): 381-381
被引量:1
标识
DOI:10.3390/molecules28010381
摘要
Furosemide (FUR), an active pharmaceutical ingredient (API) belonging to a group of drugs known as loop diuretics, has widespread use, but, is characterized by a strong instability to light, which causes chemical transformations that could give a yellowing phenomenon and have a significant impact from a health and marketing point of view. Many studies have tried to explain this phenomenon under different experimental conditions, but no detailed explanation of the yellowing phenomenon has been provided. This work, unlike the others, provides an overall view and explanation of the behavior of FUR in relation to the yellowing phenomenon, both in the solution and in solid state, considering several aspects, such as light exposure, presence of oxygen, and moisture effects.
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