血糖性
糖尿病
2型糖尿病
医学
昼夜节律
联想(心理学)
睡眠(系统调用)
内科学
内分泌学
老年学
心理学
计算机科学
心理治疗师
操作系统
作者
Dorit Koren,Kristen L. Knutson,Brian Burke,Kimberly L. Drews,Fida Bacha,Lorraine E. Levitt Katz,Marsha D. Marcus,Siripoom McKay,Kristen J. Nadeau,Babak Mokhlesi
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2024-04-12
标识
DOI:10.1152/ajpheart.00550.2023
摘要
We aim to examine the association of sleep duration, sleep quality, late chronotype and circadian misalignment with glycemic control and risk of complications in young adults with youth-onset type 2 diabetes followed in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Self-reported sleep duration, quality, timing, and circadian misalignment were assessed via a modified Pittsburgh Sleep Quality Index (PSQI) questionnaire, and chronotype was assessed via the Morningness-Eveningness Questionnaire (MEQ). We examined diabetes complications including loss of glycemic control (defined as hemoglobin A1c ≥8%), hypertension, dyslipidemia, albuminuria, and diabetic peripheral neuropathy. Multivariable logistic regression models were constructed to assess associations between sleep and circadian measures with outcomes of interest, such as loss of glycemic control and diabetes complications. A total of 421 participants (34.2% male), mean age 23.6±2.5 years, mean BMI of 36.10±8.26 kg/m2 and mean diabetes duration of 10.0±2.5 years were evaluated. Self-reported short sleep duration, daytime sleepiness, and sleep quality were not associated with loss of glycemic control or diabetes complications. Late self-reported bedtime (after midnight) on work/school nights, rather than self-expressed chronotype or circadian misalignment, was independently associated with loss of glycemic control. An association was seen between late bedtimes and albuminuria but was attenuated after adjusting for depression. In conclusion, late bedtime on work/school days, rather than short sleep duration, daytime sleepiness, or poor sleep quality, was independently associated with loss of glycemic control in this longitudinal cohort of young adults with youth-onset type 2 diabetes.
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