转座因子
生物
进化生物学
背景(考古学)
透视图(图形)
生物进化
进化动力学
DNA转座因子
基因组
遗传学
基因
人口
社会学
人口学
计算机科学
人工智能
古生物学
作者
Andrea J. Betancourt,Kevin H.-C. Wei,Yuheng Huang,Yuh Chwen G Lee
出处
期刊:Annual Review of Genomics and Human Genetics
[Annual Reviews]
日期:2024-04-11
标识
DOI:10.1146/annurev-genom-120822-105708
摘要
Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes, including humans. This evolutionary success of TEs is due to their replicative activity, involving insertion into new genomic locations. TE activity varies at multiple levels, from between taxa to within individuals. The rapidly accumulating evidence of the influence of TE activity on human health, as well as the rapid growth of new tools to study it, motivated an evaluation of what we know about TE activity thus far. Here, we discuss why TE activity varies, and the consequences of this variation, from an evolutionary perspective. By studying TE activity in nonhuman organisms in the context of evolutionary theories, we can shed light on the factors that affect TE activity. While the consequences of TE activity are usually deleterious, some have lasting evolutionary impacts by conferring benefits on the host or affecting other evolutionary processes.
科研通智能强力驱动
Strongly Powered by AbleSci AI