光遗传学
被盖腹侧区
中缝背核
神经科学
伏隔核
谷氨酸的
兴奋性突触后电位
中缝核
多巴胺
心理学
5-羟色胺能
医学
抑制性突触后电位
谷氨酸受体
多巴胺能
内科学
血清素
受体
作者
Di Liu,Su-Wan Hu,Di Wang,Qi Zhang,Xiao Zhang,Huiping Ding,Jun‐Li Cao
标识
DOI:10.1523/jneurosci.0869-23.2023
摘要
The dorsal raphe nucleus (DRN) is an important nucleus in pain regulation. However, the underlying neural pathway and the function of specific cell types remain unclear. Here, we report a previously unrecognized ascending facilitation pathway, the DRN to the mesoaccumbal dopamine (DA) circuit, for regulating pain. Chronic pain increased the activity of DRN glutamatergic, but not serotonergic, neurons projecting to the ventral tegmental area (VTA) (DRN Glu -VTA) in male mice. The optogenetic activation of DRN Glu -VTA circuit induced a pain-like response in naive male mice, and its inhibition produced an analgesic effect in male mice with neuropathic pain. Furthermore, we discovered that DRN ascending pathway regulated pain through strengthened excitatory transmission onto the VTA DA neurons projecting to the ventral part of nucleus accumbens medial shell (vNAcMed), thereby activated the mesoaccumbal DA neurons. Correspondingly, optogenetic manipulation of this three-node pathway bilaterally regulated pain behaviors. These findings identified a DRN ascending excitatory pathway that is crucial for pain sensory processing, which can potentially be exploited toward targeting pain disorders.
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