电感耦合等离子体质谱法
介孔材料
微球
质谱法
粒子(生态学)
介孔二氧化硅
多孔性
粒径
感应耦合等离子体
化学
纳米颗粒
材料科学
色谱法
纳米技术
分析化学(期刊)
化学工程
等离子体
催化作用
有机化学
海洋学
物理
物理化学
量子力学
工程类
地质学
作者
Shin-ichi Miyashita,Toshihiko Ogura,Shun-ichi Matsuura,Eriko Fukuda
出处
期刊:Molecules
[MDPI AG]
日期:2024-02-29
卷期号:29 (5): 1086-1086
标识
DOI:10.3390/molecules29051086
摘要
Single-particle inductively coupled plasma mass spectrometry (spICP-MS) has been used for particle size measurement of diverse types of individual nanoparticles and micrometer-sized carbon-based particles such as microplastics. However, its applicability to the measurement of micrometer-sized non-carbon-based particles such as silica (SiO2) particles is unclear. In this study, the applicability of spICP-MS to particle size measurement of non-porous/mesoporous SiO2 microspheres with a nominal diameter of 5.0 µm or smaller was investigated. Particle sizes of these microspheres were measured using both spICP-MS based on a conventional calibration approach using an ion standard solution and scanning electron microscopy as a reference technique, and the results were compared. The particle size distributions obtained using both techniques were in agreement within analytical uncertainty. The applicability of this technique to the detection of metal-containing protein-binding mesoporous SiO2 microspheres was also investigated. Bound iron (Fe)-containing proteins (i.e., lactoferrin and transferrin) of mesoporous SiO2 microspheres were detected using Fe as a presence marker for the proteins. Thus, spICP-MS is applicable to the particle size measurement of large-sized and non-porous/mesoporous SiO2 microspheres. It has considerable potential for element-based detection and qualification of bound proteins of mesoporous SiO2 microspheres in a variety of applications.
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