Molecular hybridization: a powerful tool for multitarget drug discovery

Introduction The current drug discovery paradigm of ‘one drug, multiple targets’ has gained attention from both the academic medicinal chemistry community and the pharmaceutical industry. This is in response to the urgent need for effective agents to treat multifactorial chronic diseases. The molecular hybridization strategy is a useful tool that has been widely explored, particularly in the last two decades, for the design of multi-target drugs.