脂质体
非那雄胺
化学
渗透(战争)
渗透
药理学
色谱法
毛囊
药物输送
Zeta电位
材料科学
医学
纳米技术
纳米颗粒
内科学
生物化学
有机化学
前列腺
膜
工程类
癌症
运筹学
作者
Shweta Ramkar,Monika Kaurav,M.S. Sudheesh,Ravi Shankar Pandey
标识
DOI:10.1080/03639045.2023.2182122
摘要
Long-term treatment with finasteride (FIN) for androgenic alopecia is restricted due to its systemic side effects. To address this problem, DMSO-modified liposomes were prepared in the present study to improve the topical delivery of FIN. DMSO-liposomes were prepared by a modification of the ethanol injection method. It was hypothesized that the permeation-enhancing property of DMSO could promote drug delivery to deeper skin layer where hair follicles are present. Liposomes were optimized by quality by design (QbD) approach and biologically evaluated in a rat model of testosterone-induced alopecia. Optimized DMSO-liposomes were spherical and had mean vesicle size, zeta potential, and entrapment efficiency of 330.1 ± 1.5, -14.52 ± 1.32, and 59.02 ± 1.12%, respectively. Biological evaluation on testosterone-induced alopecia and skin histology shows that follicular density and anagen/telogen (A/T) ratio were increased in rats treated with DMSO-liposomes as compared to FIN-liposomes without DMSO and an alcoholic solution of FIN applied topically. DMSO-liposomes could be promising skin delivery vehicles for FIN or similar drugs.
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